Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt
Abstract
Background: Allergic rhinitis (AR) is an immunoglobulin E (IgE) mediated inflammatory chronic disorder of the nasal mucosa caused by contact to allergens which affects a significant percentage of population. Th17 cells might be involved in the acute phase of the allergic reaction. Th17 cells are regulated by IL-23, which is a member of the IL-12 cytokine family. IL-23 was suggested to be a pivotal cytokine involved in the pathogenesis of AR and may become a novel target in the treatment of AR. Objective: Here we investigate the role of serum IL-23 and its correlation with serum total IgE level in AR. Methodology: This case control study included the investigation of 48subjects. Blood samples were collected for measuring serum IL-23 and total IgE levels by ELISA. Results: positive correlation was found between IL-23 and total IgE serum level in AR patients. Conclusion: Positive correlation was found between serum IL-23 and serum total IgE levels in allergic rhinitis patients.
EL-Aidy, A. (2021). Correlation between serum IL-23 and serum total IgE levels in allergic rhinitis patients. Egyptian Journal of Medical Microbiology, 30(3), 59-63.
MLA
Aya M. EL-Aidy. "Correlation between serum IL-23 and serum total IgE levels in allergic rhinitis patients". Egyptian Journal of Medical Microbiology, 30, 3, 2021, 59-63.
HARVARD
EL-Aidy, A. (2021). 'Correlation between serum IL-23 and serum total IgE levels in allergic rhinitis patients', Egyptian Journal of Medical Microbiology, 30(3), pp. 59-63.
VANCOUVER
EL-Aidy, A. Correlation between serum IL-23 and serum total IgE levels in allergic rhinitis patients. Egyptian Journal of Medical Microbiology, 2021; 30(3): 59-63.
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