Neutrophil gelatinase-associated lipocalin (NGAL) role in diagnosis of complications of liver cirrhosis

Document Type : New and original researches in the field of Microbiology.

Author

Medical Microbiology & Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Abstract

Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa glycoprotein that is normally expressed at very low levels in several human tissues. NGAL comprises a critical component of innate immunity to bacterial infection acting as an acute phase protein. Also, it is one of the most promising markers for diagnosis of kidney injury.
Abbreviations:
NGAL: Neutrophil gelatinase-associated lipocalin, AKI: acute kidney injury, kDa: Kilo Dalton, ACLF: acute on chronic liver failure, LPS: lipopolysaccharides, TNF α: tumor necrosis factor alpha, SBP: spontaneous bacterial peritonitis.

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