Lecturer, Microbiology Department Medical Research Institute, Alexandria University
Abstract
Background: Methicillin-resistant Staphylococcus aureus (MRSA) colonization is considered a major risk factor for nosocomial infections and its decolonization has reduced these infections. Mupirocin (MUP) is the topical antibiotic of choice for decolonization. MUP decolonization failure is attributed to MUP resistance. Objective: The aim of the current study is to assess MUP resistance among MRSA isolates phenotypically and genotypically. Methodology: Fifty MRSA isolates were identified in Microbiology Department in the Medical Research Institute hospital, Alexandria University. Antibiotic susceptibility to different classes of antibiotics by disk diffusion method was done. MUP minimum inhibitory concentration (MIC) was determined phenotypically by MUP Ezy MIC™ Strips. MUP resistance was determined genetically by multiplex PCR detection of mupA and mupB. Results: Of all MRSA isolates, 6% exhibited high level and none showed low level MUP resistance. Only mupA was detected in all resistant isolates. Conclusion: Despite low prevalence of MUP resistance, it is appropriate to test MUP resistance prior nasal decolonization.
Attia, N. (2021). Assessment of Mupirocin Resistance among Clinical Isolates of Methicillin Resistant Staphylococcus aureus. Egyptian Journal of Medical Microbiology, 30(1), 109-114.
MLA
Nancy M. Attia. "Assessment of Mupirocin Resistance among Clinical Isolates of Methicillin Resistant Staphylococcus aureus". Egyptian Journal of Medical Microbiology, 30, 1, 2021, 109-114.
HARVARD
Attia, N. (2021). 'Assessment of Mupirocin Resistance among Clinical Isolates of Methicillin Resistant Staphylococcus aureus', Egyptian Journal of Medical Microbiology, 30(1), pp. 109-114.
VANCOUVER
Attia, N. Assessment of Mupirocin Resistance among Clinical Isolates of Methicillin Resistant Staphylococcus aureus. Egyptian Journal of Medical Microbiology, 2021; 30(1): 109-114.
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