Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University
Abstract
Background: Vulvovaginal candidiasis (VVC) is regarded as a prevalent vaginal infection and mainly results fromCandida albicans. Nevertheless, there has recently been a prominent shift in candidiasis etiology regarding non-albicans Candida (NAC) species with achieving importance. For women with more than three episodes annually are described as recurrent vulvovaginal candidiasis (RVVC). Objectives: To isolate, speciate, and determine the value of antifungal sensitivity pattern of candida species isolated from patients developed (RVVC). Methodology: High vaginal swabs (HVS) were taken from patients with RVVC and cultured on ordinary mycological media. Any significant candida growth was identified and speciated byVITEK 2 system. Their antifungal sensitivity was done by disc diffusion approach governed by CLSI guidelines. Results: A total of 110 Candida species from 250 high vaginal swabs were isolated. Among all candida species isolated from patients with RVCC, C.albicanis accounts for 44% while NAC accounts for 56% with C.glabrata most common species isolated. Voriconazole, amphotericin B, and nystatin showed high sensitivity rates (92 %, 89%, and 84% respectively) on all candida species (C.albicans and NAC) isolated from patients with RVVC. Conclusion: In RVCC there is increase in NAC (56%) with C.glabrata most common species isolated. Voriconazole, Nystatin, and amphotericin B have the best antifungal activity against all spp.
Mokhtar, G. (2021). Value of antifungal susceptibility testing in recurrent vulvovaginal Candidiasis by Non -Albicans Candida. Egyptian Journal of Medical Microbiology, 30(1), 161-167.
MLA
Ghada Abd el moniem Mokhtar. "Value of antifungal susceptibility testing in recurrent vulvovaginal Candidiasis by Non -Albicans Candida". Egyptian Journal of Medical Microbiology, 30, 1, 2021, 161-167.
HARVARD
Mokhtar, G. (2021). 'Value of antifungal susceptibility testing in recurrent vulvovaginal Candidiasis by Non -Albicans Candida', Egyptian Journal of Medical Microbiology, 30(1), pp. 161-167.
VANCOUVER
Mokhtar, G. Value of antifungal susceptibility testing in recurrent vulvovaginal Candidiasis by Non -Albicans Candida. Egyptian Journal of Medical Microbiology, 2021; 30(1): 161-167.