Correlation between Highly Sensitive C Reactive Protein and Development of Microvascular Complications of Type 2 Diabetes Mellitus

Document Type : New and original researches in the field of Microbiology.

Authors

1 Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

2 Department of Internal medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt

3 Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Abstract

Background: Microvascular problems associated with type 2 diabetes mellitus (T2DM) are a leading source of morbidity and mortality in T2DM patients, thus the search for new biomarkers to identify and treat those at high risk is intensifying. Objective: This controlled cross-sectional study aimed to investigate whether there is a correlation between serum levels of highly sensitive C reactive protein (hsCRP) and development of microvascular complications in T2DM.Methodology:  Hundred and thirty-five subjects aged from 35 to 70 years were subdivided into 3 groups. Detailed clinical history was taken. Serum levels of hsCRP were estimated using Immune Turbidimetry. Results: Serum hsCRP levels were higher in group A than other studied groups. However, there was no statistically significant difference between group A and B(P=0.35). Serum hsCRP levels were significantly higher in patients with diabetic nephropathy than patients without nephropathy (P=0.016). The difference between serum hsCRP levels in patients with and without retinopathy and neuropathy was not significant (P=0.39 and P=0.53 respectively). Conclusion: Serum hsCRP can be used as a novel marker for diagnosis of microvascular complications in T2DM patients.
Abbreviations: (T2DM: Type 2 Diabetes Mellitus, hsCRP: highly sensitive C Reactive Protein, eGFR: Estimated Glomerular filteration Rate, BUN: Blood Urea Nitrogen, HbA1c: Glycosylated Hemoglobin). 

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