The role of IL-33 in Severity of Systemic Sclerosis

Document Type : New and original researches in the field of Microbiology.

Authors

1 Microbiology and Immunology Department Faculty of Medicine Benha University

2 rehumatology and rehabilitation benha faculty of medicine benha university

3 1Department of Medical Microbiology and Immunology, Faculty of Medicine, Benha University

Abstract

Background: Systemic sclerosis (SSc) is an autoimmune connective tissue disorder characterized by sclerotic changes which affect the skin and internal organs. Interleukin-33 (IL-33) is a newly reported cytokine of the IL-1 family.  Objective: The aim of this work was to determine serum levels of IL-33 in SSc patients and evaluate its association with clinical manifestations and disease subset. Methodology: The study included two groups. Group A included 40 adult patients diagnosed asSSc, these were subdivided into diffuse systemic sclerosis (dSSc) and limited systemic sclerosis (lSSc) groups. All patients were diagnosed according to the ACR criteria for SSc. Group B included 20 healthy adult persons (age and sex matched) as the control group. All patients were selected from the Rheumatology department Benha University Hospital. Serum IL-33 levels were examined by means of enzyme-linked immunosorbent assay. Result: mean serum level of IL-33 were highly significant in SS patients in comparison to control groups [p < 0.0001]. The levels of IL-33 were significantlyhigher in the dSSc subset compared with the lSSc subset. Also there was a statistically significant correlation between disease activity and serum levels of IL33.  Conclusion: IL-33 may have a significant role in the pathogenesis of SSc. IL-33 serum levels paralleled the severity of the disease subset. Understanding of IL-33 functions is important for the development of new therapeutic approaches including IL-33 inhibitors and IL-33 receptor blockers as a therapeutic target.

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