Prevalence of Helicobacter pylori Infection in Patients with Primary Open Angle Glaucoma

Document Type : New and original researches in the field of Microbiology.

Authors

1 Department of Medical Microbiology and Immunology, Research of Institute of Opthalmology, Giza, Egypt

2 Researcher, Department of Glaucoma, Research Institute of Ophthalmology, Giza, Egypt

Abstract

Background: Primary Open-Angle Glaucoma (POAG) the most common form of glaucoma is a neurodegenerative disease, which is the third most common cause of blindness worldwide. Among the various factors that have been implicated in the pathophysiology of this disease is infection with Helicobacter pylori (HP), a Gram-negative bacterium that is commonly found in stomach and present in approximately one-half of the world’s population. This association has caused a great deal of scientific discussion during the past decades, as the establishment of such a correlation might lead to therapeutic applications for all glaucoma patients. Objective: to determine the prevalence of Helicobacter pylori (H. pylori) infection in the primary open angle glaucoma (POAG) in Egyptian cohort. Methodology: Peripheral venous blood samples were withdrawn from each participant and tested for existence of H. pylori particular immunoglobulin G antibodies by enzyme-linked immunosorbent assay in 63 cases with POAG as well as from aged matched non glaucomatous controls at the glaucoma subspecialty Clinic at the Research Institute of Ophthalmology, Giza, Egypt. Results: 63 patients (71.4% (45 cases) of them were females with POAG and 30 healthy controls (70% (11 cases) were females and were recruited in our study. Mean age was 57 for POAG patients and 46 for controls. Helicobacter pylori antibodies G were found reactive using ELISA technique in 52 out of 63 patients for POAG group (82.5%) and 13 out of 30 healthy controls (43.3%). Conclusion: High association could be reported between H. pylori and primary open-angle glaucoma suggesting a potential correlation between both.

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