Serum Mannose Receptor as a Diagnostic Bio-Marker for Sepsis in ICU Patients in Ain Shams University Hospitals

Shehata, Fatma Mohamady; El-khashab, Taghreed Hamed; Hussein, Fager Fathy; Ahmed, Yasmin Mohamed

doi:10.21608/ejmm.2022.228620

Serum Mannose Receptor as a Diagnostic Bio-Marker for Sepsis in ICU Patients in Ain Shams University Hospitals

Document Type : New and original researches in the field of Microbiology.

Authors

¹ Microbiology & Immunology, Faculty of medicine, Helwan University , Cairo, Egypt.

² Microbiology & Immunology, Faculty of medicine, Ain shams university, Cairo, Egypt.

³ Microbiology &Immunology, Faculty of medicine, Ain shams university, Cairo, Egypt.

10.21608/ejmm.2022.228620

Abstract

Background: Sepsis is one of commonest complications that is associated with extended hospital stays. Making an early diagnosis is critical for improving its prognosis. Serum Mannose Receptor (sMR) is a biological biomarker which can be used in early diagnosis of sepsis. Objective: To investigate the value of sMR as a diagnostic biomarker for sepsis. Methodology: This study included 65 patients and 25 healthy individuals as control group. The patients’ group was divided into two groups according to SIRS criteria. Blood samples from patients were collected for blood cultures. sMR levels were measured in patients and control groups. Results: The commonest isolated organism by blood culture was S. aureus. SMR levels among cases in the both groups were higher than controls with statistically significant difference. SMR could be used to discriminate cases in both groups with 97.5% sensitivity, 80.0% specificity. Conclusion: sMR is a promising biomarker in early predictor of sepsis.

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