Do Interferon Regulatory Factors 3 and 7 Play Role in Breast Cancer?

Document Type : New and original researches in the field of Microbiology.

Authors

1 Oncology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

2 Medical Microbiology & Immunology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

3 Clinical Pathology Department, Faculty of Medicine, Suez Canal University; Ismailia, Egypt

Abstract

Background: Breast cancer is a disease whose progression varies from atypical ductal hyperplasia to ductal carcinoma in situ and invasive ductal carcinoma. Interferon regulatory factor-3mediated apoptosis is independent of IFN or p53 and a big debate about whether IRF3 is considered as a tumor suppressor gene or not. The IRF7 level was shown to be silent in some metastatic breast cancer cell lines as it was proved that silencing of IRF7 in breast cancer cells promotes bone metastasis. Objective: We conducted this work to study the effect of IRF3and IRF7 in disease progression of cancer breast. Methodology: IRF3 and IRF7 were measured in 48 cancer breast patients and 48 normal control persons by using ELISA technique. Paraffin block for the breast tumor was done for all cases to assess the stage and the grade of cancer. Distant metastasis was diagnosed through chest x-ray, abdominal sonography and bone scan. Results: It was found that IRF3 and IRF7 were higher in advanced breast cancer compared with normal control group. Conclusion: To assess the effect of IRF3 and IRF7 in breast cancer is still in need for more researches.

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