Role of High Mobility Group Box1 in Pathogenesis of Hepatitis C Virus induced Hepatocellular Carcinoma

Document Type : Review articles

Authors

1 Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University

2 Hepatology & Gastroenterology unit, Faculty of Medicine, Mansoura University

DOI:https://doi.org/10.51429/EJMM29417

Abstract

Hepatocellular carcinoma "HCC" is a leading cause of cancer mortality worldwide. High-mobility group box 1 "HMGB1" is a nuclear DNA-binding protein which involved in DNA stability, programmed cell death, immune response and inflammatory responses in HCV and HCC. Its over expression was revealed in HCC and different types of human cancers.

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