Evaluation of the Antimicrobial Activity of Citric Acid Functionalized Magnetite Nanoparticles

El-Khawaga, Ahmed M.; Farrag, Ayman A.; El-Batal, Ahmed I.; Elsayed, Mohamed A.

doi:10.51429/EJMM29418

Evaluation of the Antimicrobial Activity of Citric Acid Functionalized Magnetite Nanoparticles

Document Type : New and original researches in the field of Microbiology.

Authors

¹ Chemical Engineering Department, Military Technical College, Egyptian Armed Forces, Cairo, Egypt

² Professor & Chairman of Microbiology Department, Faculty of Science Al-Azhar University, Cairo, Egypt; Director of Al-Azhar Center for Fermentation Biotechnology and Applied Microbiology, Cairo, Egypt

³ Drug Microbiology Lab., Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt

10.51429/EJMM29418

Abstract

Background: Antimicrobial resistance (AMR) has emerged as one of the principal public health problems of the 21st century that threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria no longer susceptible to the common medicines used to treat them. Objectives: To development of Fe3O4 NPs with specific sizes and shapes Potential as a new antibacterial agent. Methodology: In this study magnetite nanoparticles (Fe3O4 NPs) were synthesized through an aqueous co-precipitation method and functionalized with citric acid for outstanding their antimicrobial potential. Fe3O4 NPs were characterized by XRD, TEM, SEM, EDX and FTIR to analyze crystallinity, average particle size, morphology and functional groups, respectively. Antimicrobial activity was investigated against pathogenic bacteria as zone of inhibition (ZOI) and minimum inhibitory concentration (MIC). Results: Antimicrobial results showed that CA- Fe3O4 NPs owns maximum activity against Staphylococcus aureus and E. coli by 18.0 and 15.0mm ZOI, respectively. Conclusion: It should be noted that (CA-Fe3O4) NPs are also active upon Gram-positive than Gram- negative bacteria. The synthesized (CA-Fe3O4) NPs are promising for potential applications as antimicrobial agent and in drug delivery fields.

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