HLA DRB1 Alleles in Association with Chronic Hepatitis C Virus Infection and Autoimmune Hepatitis

Document Type : New and original researches in the field of Microbiology.

Authors

1 Medical Microbiology and Immunology Faculty of Medicine Alexandria University

2 Medical Microbiology and Immunology Department, Faculty of Medicine, University of Alexandria, Egypt

3 Clinical Pathology, Armed Forces Medical Academy, Alexandria, Egypt

4 Faculty of Medicine Alexandria University

5 Medical microbiology and immunology, faculty of medicine, Alexandria university

Abstract

Background: Hepatitis C virus is a hepatotropic and lymphotropic virus that has been associated with various diseases and syndromes. Autoimmune hepatitis is a chronic disease of unknown etiology, marked by the continuous inflammation of hepatocytes and necrosis and has a tendency to advance to cirrhosis. Objective: A comparative study between cases of chronic HCV infection and AIH cases regarding different parameters including their genetic association with HLA class II alleles: DRB1*01* - DRB115. Methodology: The study included Eighty subjects, Group I: 30 chronic HCV, Group II: 30 AIH, Group III: 20 healthy controls. HLA Typing was performed using a line probe assay. Results: HLA DRB1∗07, DRB1∗11 were highly associated with HCV clinical cases. DRB1*3 and DRB1*5 were the predominant alleles in AIH (representing 66.7% and 53.3% respectively). Conclusion: Certain HLA alleles of class II could be linked to hepatitis cases (either caused by HCV or autoimmune) and can predict clinical course and outcome of the disease.

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