Genetic polymorphism in IL-28 B and LMP-7 genes: Role in HCV-induced Hepatocellular Carcinoma

Document Type : Review articles

Authors

1 Medical Microbiology & Immunology Department, Faculty of Medicine, Mansoura University, Egypt

2 Tropical Medicine Department, Faculty of Medicine, Mansoura University, Egypt

Abstract

Hepatocellular carcinoma (HCC) is a major health problem that differs epidemiologically across the world. Its pathogenesis is contributed to many factors, and chronic hepatitis viral infections which considered the main risk factor in Egypt. Host genetic factors are considered the most important determinants for the development of HCC especially Single-nucleotide polymorphisms (SNPs). Hepatitis C Virus (HCV) infection is a major health problem with 185 million people infected globally based on the estimation of the World Health Organization (WHO). Persistent infection with HCV can cause liver cirrhosis and/or hepatocellular carcinoma (HCC). HCC is considered the fifth most common type of cancer, killing about 600,000 patients every year. About 30% of HCV- infected patients clear the infection naturally, while the remaining 70% develop chronic disease of which 1 - 2% experience HCC. Determining HCV-infected patients are at risk of developing HCC is crucial whose need continuing surveillance for early detection and treatment of HCC and other liver disease. A number of factors including viral, environmental, and genetic factors, work together to determine the progression of disease in HCV infection.

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