Background: Long term immunity of Hepatitis B vaccine, the first vaccine to prevent cancer is a debate. Objective: to assess anti-HBs level in previously vaccinated Health Care Workers (HCWs) and Medical Students (MS). Also, determine the effect of a booster dose on humoral and cell mediated immunity in non seroprotected subjects. Methodology: A cross sectional study included 120 vaccinated HCWs and MS. HBsAg, Anti-HBs level and Interferon γ (IFN-γ) were assessed. Anti-HBs and Interferon γ (IFN-γ) levels were reassessed after a booster dose to non seroprotected subjects. Results: 90% of HCWs and 23.3% of MS were seroprotected. Boosted HCWs and MS showed significant increase in Geometric Mean Titer (GMT) of anti-HBs level (P=0.028, P<0.001 respectively), while IFN-γ mean concentration level (MCL) increased significantly in MS group only (P=0.01). Conclusion: AntiHBs level decreases significantly over time. Long term memory was found to be still intact after a booster dose.
Abou Khatwa, M., Raouf, M., & Ouf, N. (2019). What is the current Immune Status of HBV Vaccinees in Health Care Workers and Medical Students in Alexandria University, Egypt?. Egyptian Journal of Medical Microbiology, 28(3), 1-7. doi: 10.21608/ejmm.2019.282765
MLA
Malak A. Abou Khatwa; May M. Raouf; Nancy M. Ouf. "What is the current Immune Status of HBV Vaccinees in Health Care Workers and Medical Students in Alexandria University, Egypt?". Egyptian Journal of Medical Microbiology, 28, 3, 2019, 1-7. doi: 10.21608/ejmm.2019.282765
HARVARD
Abou Khatwa, M., Raouf, M., Ouf, N. (2019). 'What is the current Immune Status of HBV Vaccinees in Health Care Workers and Medical Students in Alexandria University, Egypt?', Egyptian Journal of Medical Microbiology, 28(3), pp. 1-7. doi: 10.21608/ejmm.2019.282765
VANCOUVER
Abou Khatwa, M., Raouf, M., Ouf, N. What is the current Immune Status of HBV Vaccinees in Health Care Workers and Medical Students in Alexandria University, Egypt?. Egyptian Journal of Medical Microbiology, 2019; 28(3): 1-7. doi: 10.21608/ejmm.2019.282765