Background: Cancer immunotherapy became a promising alternative to old therapeutic options in hepatocellular carcinoma. DC-DRibbles vaccine has clinical applications across a broad range of malignancies. Objective: To compare the efficacy of subcutaneous and intranodal routes of injection of Dendritic Cells-DRibbles immunotherapy in HCC induced mice. Methodology: This experimental study was conducted on 24 BALB/c mice. Healthy as negative control and cancer induced. The later was subdivided into two groups: positive control group and vaccinated groups (A and B) according to route of administration. Results: The mean of percentage of tumor volume reduction was 92.76% in DC+ Dribbles intranodal group (B), which was better than mean of percentage of change in subcutaneous group (A) which was 90.87%. Conclusion: DC- Dribbles vaccine was effective as HCC immunotherapy, both subcutaneous and intra nodal routes had comparable results. This study recommends subcutaneous route over intranodal route immunotherapy; it is simple, less invasive and effective.
Gawish, A., Meawed, T., El Shahaway, A., & Ahmed, N. (2019). Subcutaneous Versus Intranodal Dendritic Cells- DRibbles Vaccination of Hepatocellular Carcinoma in Animal Model. Egyptian Journal of Medical Microbiology, 28(3), 149-154. doi: 10.21608/ejmm.2019.283185
MLA
Awny A. Gawish; Takwa E. Meawed; Alia A. El Shahaway; Naglaa M. Ahmed. "Subcutaneous Versus Intranodal Dendritic Cells- DRibbles Vaccination of Hepatocellular Carcinoma in Animal Model". Egyptian Journal of Medical Microbiology, 28, 3, 2019, 149-154. doi: 10.21608/ejmm.2019.283185
HARVARD
Gawish, A., Meawed, T., El Shahaway, A., Ahmed, N. (2019). 'Subcutaneous Versus Intranodal Dendritic Cells- DRibbles Vaccination of Hepatocellular Carcinoma in Animal Model', Egyptian Journal of Medical Microbiology, 28(3), pp. 149-154. doi: 10.21608/ejmm.2019.283185
VANCOUVER
Gawish, A., Meawed, T., El Shahaway, A., Ahmed, N. Subcutaneous Versus Intranodal Dendritic Cells- DRibbles Vaccination of Hepatocellular Carcinoma in Animal Model. Egyptian Journal of Medical Microbiology, 2019; 28(3): 149-154. doi: 10.21608/ejmm.2019.283185