Association of Human Cytomegalovirus with Hepatitis C Virus Infections and Its Impact on Antiviral Therapy

Document Type : New and original researches in the field of Microbiology.

Authors

1 Medical Microbiology & Immunology Faculty of Medicine, Cairo University, Cairo, Egypt

2 Hepatology & Gastroenterology National Hepatology & Tropical Medicine Research Institute (NHTMRI),Cairo,Egypt

Abstract

Background: CMV infection enhances HCV pathogenesis by preventing the normal mechanisms responsible for HCV clearance, thus playing vital role in HCV persistence and pathogenicity. Objective: To examine the effect of HCV - CMV coinfection on outcome of treatment with pegylated interferon alpha and Ribavirin in chronic HCV patients. Methodology: The study included of 50 cases selected from Outpatient Clinic of The National Hepatology and Tropical Medicine Research Institute (NHTMRI). Two groups were classified group 1 (positive HCV PCR and negative CMV Ig G) and included 15 patients versus group 2 (positive HCV PCR and positive CMV Ig G) and included 35 patients. Results: The non responders to treatment were higher in group 2 (65.7 %) than in group 1 (53.3 %) but with no statistical significance. Conclusion: CMV co-infection may influence the HCV treatment outcome, despite it failed to have statistical significance.

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