Role of IL17A in Candidemic Patients in ICU at Benha University Hospital

Document Type : New and original researches in the field of Microbiology.

Authors

1 Department of Medical Microbiology and Immunology, Faculty of medicine - Benha University

2 Department of Anesthesia and ICU Faculty of Medicine - Benha University

Abstract

Background: IL-17 plays a major protective role against fungal infection in mice and humans. Genetic defects involving IL-17 increase the susceptibility to candidiasis. Objective: This study aimed at assessing the association between serum Interleukin-17A (IL17A) and candida infection in Intensive Care Unit patients with candidemia versus non-candidemic patients. Methodology: 90 individuals were included; 60 ICU patients, divided into 2 groups; group1: 30 patients with Candidemia, group 2: 30 patients with Candida in sputum and/or urine samples and 30 apparently healthy as a control group. All enrolled individuals underwent history taking, physical examination, laboratory assessment for Candida albicans infection and serum IL-17A. Results: IL17A level was significantly high among candidemia group (0.24  0.10 pg/ml) followed by group of candida in urine and sputum (0.08  0.02 pg/ml) (P-value <0.001). Conclusion: There was an association between IL-17A levels and candidemia suggesting its predictive value for a forthcoming invasive candidiasis.

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