Document Type : New and original researches in the field of Microbiology.
Authors
1
Microbiology and Immunology Department, Faculty of Pharmacy, Assiut University, Assiut
2
Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut
3
Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut
Abstract
Background: To assess the diagnostic role of serum complement factor H (CFH), complement factor D (CFD), and terminal complement complex (C5b-9) and urine C5b-9 in women diagnosed with preeclampsia (PE) and severe PE compared to normal pregnancy. Methodology: A cross-sectional study involved 89 women divided into three groups: Group I, thirty women with PE, and Group II, thirty women with severe PE. Group III consisted of twenty-nine women with normal pregnancies as a control group. Estimation of serum levels of CFH, CFD, C5b-9, and urine C5b-9 levels in different study groups was done by ELISA test. A correlation analysis was carried out between levels of complement factors, clinical data, and laboratory tests. Results: Serum CFD, CFH, C5b-9, and urine C5b-9 levels were significantly elevated in patients with PE and severe PE compared to a normal pregnancy (p <0.001). In addition, severe PE patients showed a significant increase compared to the PE group (p <0.001). A significant positive correlation was found between serum CFD, CFH, C5b-9, and urine C5b-9 with both systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patient groups. The accuracy of serum CFH, C5b-9, and urine C5b-9 in the diagnosis of severe PE was found to be 100%, while serum CFD had an overall accuracy of 98.9%. Conclusion: Serum CFH, CFD, C5b-9, and urine C5b-9 can serve as diagnostic markers for severe PE, aiding in early detection of high-risk patients, disease monitoring, and appropriate treatment.
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