Evaluation of Serum Programmed Cell Death–1 (PD-1) in Psoriasis Vulgaris: A Case-control Study

Document Type : New and original researches in the field of Microbiology.

Authors

1 Dermatology, Andrology and STDs Department, Faculty of Medicine, Mansoura University

2 Clinical Pathology Department, Faculty of Medicine, Mansoura University

Abstract

The actual mechanisms underlying the psoriasis pathogenesis and early diagnosis remain unclear. According to medical theory, psoriasis is a chronic, recurrent illness linked to T cell activation, namely T helper 1 and 17 (Th1 and Th17). The glycoprotein known as "programmed cell death-1," which is present on the surface of many immune cells, including T cells, reduces effector T cell activity and increases that of regulatory T cells.
Thirty psoriatic patients and thirty healthy volunteers were selected as controls from the Dermatology, Andrology, and STDs department's outpatient clinic at Mansoura University Hospitals. For every patient and control group, the following information was collected: age, sex, unique behaviors, family history, and length of illness. The Psoriasis Area and Severity Index (PASI) score was used to determine the severity of psoriasis. Every participant has completed a serum PD-1 laboratory test.There was no statistically significant difference between studied groups as regard serum PD-1. There was a statistically significant positive Thirty psoriatic patients and thirty healthy volunteers were selected as controls from the Dermatology, Andrology, and STDs department's outpatient clinic at Mansoura University Hospitals. For every patient and control group, the following information was collected: age, sex, unique behaviors, family history, and length of illness. The Psoriasis Area and Severity Index (PASI) score was used to determine the severity of psoriasis. Every participant has completed a serum PD-1 laboratory test.

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