Role of Interleukin-17 in the Pathogenesis and Progression of Coronary Artery Disease

Document Type : New and original researches in the field of Microbiology.

Authors

1 Department of Chemistry, Faculty of Science, University of Kufa / Najaf, 54001– Iraq

2 Department of Physical Education and Sport Science, Shahre - e - Qods Branch, Islamic Azad University, Iran

Abstract

Background: Coronary artery disease (CAD) remains one of the leading causes of morbidity and mortality worldwide. Inflammation is a critical component of CAD pathogenesis, with interleukin-17 (IL-17) emerging as a key pro-inflammatory cytokine involved in various autoimmune and inflammatory diseases. Objective: This study investigates the role of IL-17 in CAD, examining its potential as a biomarker for disease severity and its mechanistic contribution to atherosclerosis. Methodology: A case-control study with 138 subjects, including 88 (CAD) patients, and 50 apparently healthy individuals age between 40-75 years, was conducted. IL-17 level were measured using (ELISA) technique. Results: higher serum IL-17 concentration was significantly observed in patients (20.0567±4.4118 pg/ml) compared with that found in the apparently healthy group (12.9072±4.0378pg/ml) (P ≤ 0.0001). Serum IL-17 level had significant positive correlations with age, atherogenic index, lipid profile (Total cholesterol ,TG, LDL-C,VLDL-C . while showing significant negative correlations with high-density lipoprotein (HDL-C) levels in the CAD group. The results of the receiver operating curve (ROC) and AUC analysis for CETP as a potential diagnostic parameter showed a sensitivity of 79.10%, a specificity of 76%, and AUC 0.880 at a level of ≥ 16.0837pg/ml. Conclusion: elevated levels of serum IL-17 in the bloodstream may serve as a predictive indicator of the likelihood of developing CAD. which in go to increase the danger of developing CAD.

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