Diagnostic Utility of Peptidoglycan Recognition Protein 2 (PGLYRP2) in Systemic Lupus Erythematosus Patients Attending Benha University Hospitals

Document Type : New and original researches in the field of Microbiology.

Authors

1 Department of Medical Microbiology and Immunology, Faculty of Medicine, Benha University, Egypt

2 Department of Medical Microbiology and Immunology, Faculty of Medicine, Suez University, Egypt

3 Department of Rheumatology, Rehabilitation and Physical medicine, faculty of Medicine, Benha University, Egypt

Abstract

Background: PGLYRP2 is essential for innate immune responses and contributes to the progression of chronic inflammation. Elevated PGLYRP2 levels can result in prolonged inflammation. So in individuals with SLE, the concentration of PGLYRP2 in the blood rises significantly and is linked to a higher SLEDAI score. Objectives: This work was conducted to assess the PGLYRP2 level in the SLE patient’s serum and study its association with clinical manifestations, laboratory parameters, disease activity and organ damage. Methodology: twenty-five SLE patients' blood samples were obtained, leucocytes were isolated and PGLYRP2 expression was evaluated by RT-PCR then serum PGLYRP2 levels were detected by ELISA. Twenty-five healthy participants, selected to match in age and gender, were designated as the control group. Results: PGLYRP2 expression level in the leucocytes was higher in the SLE group than in the healthy control group (p< 0.05). The gene expression in the cases group was relatively higher. Serum PGLYRP2 levels were significantly higher in cases with SLE with range between (1.34-5.73) ng /mL (p< 0.05). Conclusion: Our results support the hypothesis that PGLYRP2 contributes in the development of the pathogenesis of SLE, activity of disease. PGLYRP2 appears to serve as a useful marker with good sensitivity.

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