Hepatitis Virus-related microRNA-122 gene and Biochemical Parameters in Iraqi Patients with Hepatocellular Carcinoma

Document Type : New and original researches in the field of Microbiology.

Authors

1 Department of Biotechnology, College of Science, University of Anbar, Al-Anbar

2 Department of Biology, College of Science, University of Anbar, Al-Anbar

3 Department of Biochemistry, College of Medicine, University of Anbar, Al-Anbar

10.21608/ejmm.2024.317083.1324

Abstract

Background: Chronic HBV and HCV infections may modify hepatocyte function via comparable pathways that impact the development of hepatocellular carcinoma. Our understanding of the molecular biology of HBV and HCV, as well as the cellular signal transduction pathways affected by these illnesses, has advanced significantly. Several cancer types have aberrant expression and deregulation of microRNA-122, which raises the possibility that these molecules may function as prognostic and diagnostic biomarkers. In a global context, noninvasive biomarkers have limited application for the detection of HCC. Early identification is vital to enhance the survival percentage of individuals with HCC. Methodology: Clinical diagnosis of HCC was made, and laboratory work was done. Patients were divided into two groups: those getting therapy and those not. After that, a blood sample was taken from 24 individuals of various ages and genders. A handful of them had just been diagnosed with HCC. Results: This study was significance of HCV and HB V and liver cancer, as well as the decline in research and studies in Iraq. The microRNA-122 expression levels were marginally increased in individuals who received therapy and decreased in those who were diagnosed early and did not receive any therapy. In the first phase of hepatitis samples, the microRNA-122 expression levels were considerably lower than in standard samples, with (P < 0.0001), suggesting the possible use of microRNA-122 as a biomarker to track treatment success. It is suggested that further study should be done in this field to aid diagnosis.    Conclusion: MicroRNAs have a high degree of specificity and dependability, making them an invaluable tool for tracking illness development and recurrence as well as for early diagnosis. Additionally, these indicators may function as a predictor of HCC advancement in individuals with a history of hepatitis B or C. Our findings show that, in comparison to healthy controls, HCC patients with HBV and HCV had lower expression         levels of miR-122. Untreated HCC patients had considerably decreased expression of miR-122 compared to treated HCC patients and healthy controls.

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