Increased CD3 immunostaining associated with high grade and tumor size in colorectal carcinoma

Document Type : New and original researches in the field of Microbiology.

Authors

1 Department of Medical Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar, 64001,Iraq

2 Department of Histopathology and Forensic Medicine, College of Medicine, University of Thi-Qar, Thi- Qar, 64001,Iraq

3 Department of Community Health Technologies, College of Health and Medical Technologies, National University of Science and Technology, Thi-Qar, Iraq

10.21608/ejmm.2024.331363.1364

Abstract

Background: Colorectal cancer lacks reliable prognostic biomarkers, complicating the differentiation between aggressive and indolent tumors. While CD3+ T lymphocyte infiltration generally correlates with improved prognosis and response to immunotherapy, its specific role in tumor aggressiveness is not fully understood. Objective: This study aims to assess CD3+ T cell infiltration in benign and malignant colorectal tissues and explore its potential association with clinical outcomes. Methodology: Immunohistochemistry was used to assess CD3+ T cell staining in the stromal tissue of benign (n=24) and malignant (n=80) colorectal samples. CD3+ T cell expression was then correlated with clinic pathological data such as grade and stage. Results: CD3+ T cell infiltration was significantly higher in colorectal carcinoma than benign tissues (p=0.007). A positive association was observed between CD3+ T cell immunostaining and high tumor grade (p=0.002), while a negative correlation emerged between CD3+ T cell immunostaining and tumor size (p=0.005). No significant relationship was identified between CD3+ immunostaining and lymph node involvement. Conclusion: CD3+ T cells might be involved in the aggressiveness of malignancy. Further research is needed to determine the significance of CD3+ T cells in colorectal carcinoma and its potential as a biomarker for cancer progression.

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