A Key Role of Interleukin 34 in Patients with Chronic Kidney Disease and Lupus Nephritis

Document Type : New and original researches in the field of Microbiology.

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Department of Biology, Faculty of Science, University of Kufa, Iraq

Abstract

Background: Chronic kidney disease is a progressive condition characterized by the gradual loss of kidney function over time. It is a significant public health issue, with a prevalence estimated to be between 9-15 % worldwide. Objective: This study investigates the relation between IL-34 and chronic kidney disease with lupus nephritis. Methodology: The study included 35 healthy controls, 35 patients with chronic kidney disease, and 35 patients with chronic kidney disease and lupus nephritis who were hospitalized in ALNajaf Hospital between September 1, 2023, and January 1, 2024. ELISA has been used to assess interleukin-34 and antinuclear antibody in each person's serum. Results: The results proved that there was a significant increase (P value<0.0001) in serum levels of anti-nuclear antibodies in patients (9.158 ± 0.448 pg/ml) compared with control (0.2475 ± 0.017 pg/ml). Also, there was a higher serum levels (P value<0.0001) in patients with chronic kidney disease and lupus nephritis patients as compared with chronic kidney disease patients. Patients' levels of interleukin-34 were substantially higher (P<0.05) than those of control participants. People with lupus nephritis had significantly different blood levels of antinuclear antibodies (P<0.05). Conclusion: IL-34 has an important role in patients with chronic kidney disease with lupus nephritis.

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