Clinical Correlates of Soluble sCD163 and IL9 in Patients with Chronic Kidney Disease and Lupus Nephritis

Document Type : New and original researches in the field of Microbiology.

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Department of Biology, Faculty of Science, University of Kufa, Iraq

Abstract

Background: Chronic kidney disease is a progressive condition characterized by the gradual deterioration of renal function, leading to the accumulation of waste products in the body. This condition affects over 800 million individuals globally with a disproportionate burden on older adults, women, racial minorities, and individuals with diabetes mellitus or hypertension. Objective: the aim of this works is to study the immunological role of cluster of differentiation163 and interleukin9 in patients with chronic kidney disease and lupus nephritis. Methodology:  From 1st August 2023 until the end of January 2024, 40 healthy participants and 80 patients with chronic kidney disease and lupus nephritis were enrolled in this study at AL-Najaf Hospital.  The ELISA test was used to test sCD163 and IL9 in each patients' blood. Results: Patients' serum levels of IL9 and sCD163 were substantially higher (P<0.05) than those of control participants. There was no appreciable variations in sCD163 and IL9 between cases with lupus nephritis and those with chronic renal disease. Conclusion: Our results proved that there was an important immunological role of sCD163 and IL9 in patients with chronic kidney disease and lupus nephritis.

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