Evaluation of the Interleukin-8 and Interleukin12 Indices among Individuals Infected with Helicobacter pylori and Suffering from Gastric Ulcers

Document Type : New and original researches in the field of Microbiology.

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University of Kufa-Faculty of Science-Department of Biology-Iraq

Abstract

Background: Gastric ulcers, also known as peptic ulcers, are a common gastrointestinal condition characterized by the presence of sores or lesions in the lining of the stomach or the upper part of the small intestine. Objective: This study investigates the relation between interleukin-8 and interleukin-12 in individuals infected with Helicobacter pylori and suffering from gastric ulcers. Methodology: The study involved 30 healthy individuals and 30 individuals with Helicobacter pylori infection and gastric ulcers recruited between September 2023 and January 2024.  All individuals' serum levels were measured using the ELISA technique for detection of interleukin-8 and interleukin-12. Results: The serum levels of interleukin-8 and interleukin-12 were significantly higher (P<0.05) in patients than in healthy individuals. On the other hand, cases with gastric ulcer had significant higher (P<0.05) serum levels of IL-8 and IL-12 compared to cases only infected with H. pylori. Conclusion: In patients with stomach ulcers and H-pylori infection, IL8 and IL-12 levels were significantly higher than in controls, suggesting that these markers may be useful for diagnosis.

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