Sustainable and Green Zinc Oxide Nanoparticle Synthesis from Zingiber Officinale as a Wound Healing Accelerator

Document Type : New and original researches in the field of Microbiology.

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Department of Biology, College of Science, University of Basrah

Abstract

Background: Zinc oxide nanoparticles are believed to be very useful in combating infections. Low toxicity, increased skin penetration of the relevant molecules, and protection against harmful germs are top priorities for optimal application in wounds. Objective: The aim of this work is the green-based synthesis of Zinc oxide nanoparticles from ginger and the characterisation of the resulting nanoparticles, Methodology: In this study we examined the effect of Zinc oxide nanoparticles on the healing process and accelerated wound healing in 12 strains of Balb/c mice. The mice were divided into four groups: two control groups, consisting of a group that received no treatment and a carbomer group, and two groups, one of which received the wound antibiotic Mebo and the other received the hybrid antagonist (ZnO+Carbomer940). On days 0, 2, 4, and 6, tissue contraction and wound size were evaluated. Results: The results showed that the hybrid antagonist (ZnO+Carbomer940) increased the wound closure and healing rate by 56.9%. In addition, the histological parameters, such as re-epithelialisation, accelerated hair follicle growth, and collagen layer regeneration were distinct and obvious. The study revealed no potential damage or infection. Conclusion: Compared with MEBO ointment and other control groups ZnO nanoparticles loaded with Carbomer940 hydrogel showed the ability to accelerate wound repair and hair growth within six days.

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