Associations of Single Nucleotide Polymorphism (MMP-9 -1562 C/T rs 3918242) with the Risk of Severity in Adult Multiple Trauma ICU Admitted Patients: A Pilot Study

Aboelroos, Sara A.; Abotaqia, Amr K.; Azab, Hasnaa; Hassan, Nashwa R.

doi:10.21608/ejmm.2025.355041.1448

Associations of Single Nucleotide Polymorphism (MMP-9 -1562 C/T rs 3918242) with the Risk of Severity in Adult Multiple Trauma ICU Admitted Patients: A Pilot Study

Document Type : New and original researches in the field of Microbiology.

Authors

¹ Clinical and Chemical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt

² Department of Anesthesia and ICU, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt

³ Microbiology and Immunology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt

10.21608/ejmm.2025.355041.1448

Abstract

Background: Multiple traumas are injuries involving multiple body parts or organs, with at least one life-threatening injury. Despite advances in trauma care, complications like pneumonia can arise. Genetic variations, such as the MMP9-1562 C/T gene variant, may contribute to these complications. Objectives: This study aimed to investigate the potential association between the MMP-9 -1562 C/T gene variant (rs3918242) and the risk of developing pneumonia in critically injured patients admitted to the Intensive Care Unit (ICU). Methodology: This study included 120 participants: 40 ICU patients with multiple traumas and pneumonia, 40 with non-complicated multiple traumas, and 40 healthy controls. All participants were assessed using the Injury Severity Scale (ISS) scoring system. MMP9 levels were measured using the Human MMP-9 Quantikine ELISA Kit. The study focused on the MMP-9 -1562 C/T gene variant (rs3918242) to investigate its association with pneumonia susceptibility in severe multiple trauma patients in the ICU. Results: MMP9 levels were higher in patients with complicated multiple trauma and pneumonia, the T allele increased complication risk and WBC, CRP, and MMP9 levels helped differentiate between complicated and non-complicated trauma cases. Conclusion: Our study suggests a link between the MMP9-1562C/T gene variation and pneumonia risk in severely injured ICU patients. The T allele may be a genetic indicator for pneumonia risk in these patients.

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