Document Type : New and original researches in the field of Microbiology.
Authors
1
Analysis and Laboratories Department, Higher Technological Institute of Applied Health Sciences in Sohag, Ministry of Higher Education, Cairo, Egypt
2
Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Sohag University
3
Gasteroenterology and Endoscopy Department, King Salman Hospital, Riyadh First Health Cluster, MOH, KSA
Abstract
Background: Infection with hepatitis A virus (HAV) occurs worldwide and is the most common cause of acute hepatitis. Egypt is considered an area of high prevelance for HAV infection, with the highest prevalence of infection in early childhood. Objective: the aim of the work is to study the viral effect and pathophysiological changes in the liver as a result of HAV infection in children in Upper Egypt. Methodology: It is a case-control study of 250 children with suspected HAV infection confirmed by HAV-IgM using enzyme-linked immunosorbent assay (ELISA). In order to investigate liver pathophysiology before starting the treatment protocol, fifty affected children were randomly selected to undergo biochemical tests, including Alanine aminotransferase, Aspartate transaminase, alkaline phosphatase, Gamma glutamyl transpeptidase, total bilirubin, direct bilirubin, Lactate dehydrogenase, and total Leukocyte count. These tests were performed after 1 and 2 weeks of treatment, and the results were compared with 25 children who were confirmed to have no antibodies to HAV as proof. Result: Our results showed that 70 (28%) children were infected with hepatitis A virus. Our findings demonstrated that the levels of HAV-IgM, total Leukocyte count, Alanine aminotransferase, Aspartate transaminase, alkaline phosphatase, Gamma glutamyl transpeptidase, total bilirubin and direct bilirubin all had strong statistical significance between normal and HAV-infected children. While our results showed that there are no statistical differences between children after third week of treatment and normal children in in the level of HAV-IgM, total Leukocyte count, Alanine aminotransferase, Aspartate transaminase, alkaline phosphatase, Gamma glutamyl transpeptidase, total bilirubin and direct bilirubin. Accordingly, the vital functions of the liver improved to normal after the third week of treatment for HAV. Conclusion: After the third week of treatment (liver support, multivitamins), the liver functions of HAV infected children well be full recovered.
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