Association between the RETN Polymorphisms and Breast Cancer Susceptibility

Document Type : New and original researches in the field of Microbiology.

Authors

1 Genetic Engineering and Biotechnology Institute, Baghdad University, Iraq; Tropical Biological Research Unit/College of Science, Baghdad University, Iraq

2 Genetic Engineering and Biotechnology Institute, Baghdad University, Iraq

Abstract

Background: Resistin (RETN), a cysteine-rich adipokine secreted by macrophages or adipose tissue, is expressed via the RETN gene with single nucleotide polymorphisms in 3'-untranslated and RETN promoter locations. Objective: To estimate the relationship between Breast Cancer (BC) in Iraqi patients and RETN single nucleotide polymorphisms. Methodology: A study involving 100 women with BC at Al-Amal Hospital in Iraq analyzed RETN nucleotide polymorphisms from June to October 2023.
Results: Comparison of RETN (rs10401670 T/C) genotypes and alleles between patients with BC and HCs revealed that TC and CC genotypes had significant relations with BC (p< 0.001 and p < 0.001, respectively); the rates of TC and CC genotypes were higher in patients in comparison with HCs, 53 versus 34 and 25 versus 10, respectively, therefore both of them acts as a risk factor with odds ratios of 3.97 (2.06 -7.64) and 6.36 (2.63 -15.40), respectively. The TT genotype was significant protective factor against BC with a ratio of odds: 0.22 (0.12 -0.41) and (p< 0.001); allele analysis revealed that allele T was significant protector with a ratio of odds of 0.35 (0.23 -0.53) and (p<0.001). Conclusion: RETN (rs10401670 T/C) is the only SNP that has a significant impact on cancer risk. Other SNPs, rs3745369 G/C, rs368504053 T/C, and rs74489689 A/G, were not significantly associated with BC.  

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