Multi-drug Resistant Catheter-related Infection Is a Common Culture Finding and Infective Endocarditis is associated with Delayed recovery and Mortality

Abdelmohsen, Waleed; Kamel, Cherry; Tohami, Nahla; Ibrahim, Bassant; Abdelmegied, Shaimaa Z.

doi:10.21608/ejmm.2025.361199.1486

Multi-drug Resistant Catheter-related Infection Is a Common Culture Finding and Infective Endocarditis is associated with Delayed recovery and Mortality

Document Type : New and original researches in the field of Microbiology.

Authors

Internal Medicine and Nephrology Department, Faculty of Medicine, Ain Shams University, Cairo-Egypt.

10.21608/ejmm.2025.361199.1486

Abstract

Background: The second most common cause of mortality in dialysis patients is infection, and using a central venous catheter for haemodialysis is linked to higher infection rates. Objective: This study assessed the bacterial spectrum of hemodialysis catheter-related infection and its relation to patients’ outcomes. Methodology: A prospective study included 57 hemodialysis patients with catheter-related infections excluding Patients with evident sepsis by other causes. Results: The most common organisms were multidrug-resistant (MDR) Enterobacteriaceae and Staphylococci at 40.4% (23 patients) while drug-sensitive Staphylococci and Enterobacteriaceae were at 35.1% (20 patients) and 24.6% (14 patients) respectively. The prevalence of Infective endocarditis (IEC), septic emboli, and mortality were 10.5% (6 patients), 7.0% (4 patients), and 8.8% (5 patients) respectively. The duration of more than 55 days of catheter insertion was associated with risk 13 times to get IEC (odds ratio: 13.214). The median time for recovery was 7 (7 – 15) days, and there was a significant difference as regards time for recovery between MDR, Staphylococci, and Enterobacteriaceae P-value (0.020). Post-hoc analysis showed a significantly longer time for recovery in MDR versus Enterobacteriaceae and Staphylococci P-value 0.013 & 0.030 respectively while no significant difference between Enterobacteriaceae and Staphylococci P-value 0.804. The period of recovery in patients with temporary catheters was positively correlated with CRP (r 0.840, p 0.036).Conclusion: Multidrug-resistant Catheter-related infection is a common culture finding. IEC and MDR organisms are associated with delayed recovery, moreover IEC was associated with a high mortality rate.

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