Inflammatory Biomarkers as Prognostic and Predictive Factor in Patients with COVID-19

Document Type : New and original researches in the field of Microbiology.

Authors

1 College of Health and Medical Techniques, Baghdad, Middle Technical University, Baghdad, Iraq

2 Department of Medical Laboratory Techniques, College of Health and Medical Techniques/ Kufa, Al-Furat Al-Awsat Technical University, 31003 Al-Kufa, Iraq

Abstract

Background: COVID-19 severity is often linked to excessive inflammatory responses. Biomarkers such as C-reactive protein (CRP), IL-17, and IL-33 have potential roles in inflammation and disease progression. Identifying these biomarkers may help predict disease severity and guide clinical management. Objective:  This study aimed to investigate the role of CRP, IL-17, and IL-33 as indicator factors for Covid-19 severity. Methodology: The study involved ninety-five Covid-19 patients divided into mild and severe, along with (50) healthy controls.  Levels of CRP, IL-17 and IL-33 were measured by ELISA in patients and healthy controls. Results: The results of the study indicated highly significant relation between the Covid-19 groups and healthy controls regarding C-reactive protein levels, as well as Il-17 and IL-33. Conclusion: The biomarkers are highly associated with Covid-19. Increased levels of IL-17, IL-33 facilitates lung injury through production other pro-inflammatory cytokines and that explain the immunopathology of Covid-19 infection, so could be used as a predictive factor for intensity of disease in patients with COV1ID-19.

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