Evaluation of Interleukin 17A Gene (rs 2275913) polymorphism in Patients with Diabetic Foot Ullcer

Document Type : New and original researches in the field of Microbiology.

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Department of Medical Microbiology, College of Medicine, University of Karbala, Karbala, Iraq

Abstract

Background: Diabetic foot ulcer (DFU) is one of the most serious complications – occur on the foot of individuals with diabetes, leading to infections, hospitalization and even amputation if not properly managed. Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that plays a crucial role in the development of autoimmune and inflammatory diseases and in the immune responses against infections. Objective: The current study aimed to explore the relation of the IL-17A (rs2275913) G/A gene polymorphism with severity and progression of foot ulcers caused by diabetes. Methodology: This case-control research included 35 cases of ulcerated diabetic feet and 35 healthy Individuals as a control. DNA extraction was done to reveal the polymorphism of the IL-17A gene by allele-specific polymerase chain reaction. Results: A statistically significant difference (P = 0.095) was observed between the study groups regarding the genotypes of IL-17A gene polymorphism. The AA and GA genotypes were more prevalent in cases, although the frequency of GG genotypes was higher in controls compared to patients. The frequency of the A allele was elevated in patients compared to controls. Conversely, the allele G was less prevalent in cases compared to the control group, yielding a significant result (P=0.0187). Conclusion: This study demonstrated that the AA genotype was more prevalent in patients with diabetic foot ulcer compared to the control group. Thus, it is possible that the AA genotype contributes to the risk of diabetic foot ulcer.

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