Biochemical and Histological Changes of Liver in Male Albino Rats Infected by Leishmania donovani

Document Type : New and original researches in the field of Microbiology.

Authors

College of Science, Babylon University, Iraq

10.21608/ejmm.2025.379889.1598

Abstract

Background: The protozoan parasite Leishmania is the cause of leishmaniasis. Humans contract it by the bite of sand flies, which are bloodsucking insects. Iraq is among the many places on the globe where visceral leishmaniasis (VL) is prevalent. Objective: The study's goal was to look at the histological and biochemical effect caused by Leishmania donovani in male albino ratsMethodology: Twenty mice were divided into 4 groups (n = 5): G1 and G3 were considered as the control group that was given distilled water once at 30 and 60 days, respectively, and G2 and G4 were infected with (2 × 107) parasites per mouse once at 30 and 60 days, respectively. These animals were sacrificed on days 31 and 61 post-infection (Pi.). Results: When compared to control groups, biochemical data demonstrated a significant rise in glutamic pyruvic transaminase (GPT) activity and a considerable decrease in glutamic oxaloacetic transaminase (GOT) activity. Histological results of liver in G2 showed interface hepatitis and hyaline degeneration while G4 showed ballooning degeneration of hepatocyte as compared with control group. Conclusion: Through the involvement of the liver, leishmaniasis causes alterations in tissue form and function in the host. Understanding these modifications is crucial in finding the effective mechanisms of the parasite and host interaction.

Keywords

Main Subjects

Files

Share

How to cite

Statistics