The Correlation between Heat Shock Protein and Oxidative Stress in Entamoeba Histolytica Patients

Document Type : New and original researches in the field of Microbiology.

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Department of Pathological Analyses, Faculty of Science, University of Kufa, Najaf, Iraq

Abstract

Background: Entamoeba histolytica causes amebiasis, a dangerous diarrheal disease. This is a major health problem in areas with poor sanitation and overcrowding, leading to many infections and deaths worldwide. HSP70, a key protein for protein management in all organisms, handles folding and transport. Objectives: This study aimed to determine the relationships between heat shock protein and entamoeba histolytica patient. Methodology: A case-control study to measure heat shock protein levels in Entamoeba histolytica-infected patients was conducted at Al-Amin center between September 2024 and January 2025 to measure heat shock protein levels in Entamoeba histolytica infected patients. 110 blood samples were collected from multiple hospitals within Al-Najaf, and 50 tested positive for the parasite. 3mL of serum was extracted from each positive sample, and stored at -80°C for later heat shock protein analysis. Results: heat shock protein levels were markedly higher (4.552±0.807) in E. histolytica-infected patients than in controls (1.959±0.236). Conclusions: The research demonstrated that individuals infected with Entamoeba histolytica had considerably higher levels of heat shock proteins70 compared to those in the control group.

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