Interleukin1β and Tumor necrosis factorα as Candidate Biomarkers for Discriminating Rheumatoid Arthritis in Iraqi Patients

Document Type : New and original researches in the field of Microbiology.

Authors

1 Department of Biology, College of Science, University of Al-Qadisiyah, Iraq

2 Department of Surgery, College of Medicine, University of Al-Qadisiyah, Iraq

Abstract

Background: Rheumatoid arthritis (RA) is a systemic, Auto immune and inflammatory disease, which produces chronic synovial inflammation leading to progressive joint damage and functional deficit. Objective: The aim of this study was to determine the value serum IL-1β and TNF-α level for the diagnosis of RA in the Iraqi population. Methodology: 75 patients with RA were compared with 75 age and sex matched healthy control, in a case control study. Serum from all subjects was obtained and the levels of IL-1β and TNF-α were determined by ELISA. Results: The serum levels of IL-1β and TNF-α were markedly elevated in RA patients compared with HCs (p7. 09 ng/mL, with a sensitivity of 72% and specificity of 89.3%, and a TNF-α cutoff value of >1578.26 ng/mL, with a sensitivity of 57.3% and specificity of 90.7%, for diagnosing RA. Cytokine levels were not significantly associated with the disease of study subjects or their gender (ps> 0.05). Conclusion: This results illustrates that serum concentrations of IL-1β and TNF-α in the Iraqi population can be considered as useful biomarkers for diagnosis of patients with RA.

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