Investigation of IgA, IL-9, IL-13, and hs-CRP Levels Among Asthmatic Patients with Recurrent Respiratory Tract Infections in Southern Regions of Iraq

Uoda, Hussian Y.; Al-Ammar, Nibras S.; Salman, Ali N.; Kreyenberg, Hermann; Bader, Peter

doi:10.21608/ejmm.2025.386046.1655

Investigation of IgA, IL-9, IL-13, and hs-CRP Levels Among Asthmatic Patients with Recurrent Respiratory Tract Infections in Southern Regions of Iraq

Document Type : New and original researches in the field of Microbiology.

Authors

¹ Microbiology Department/College of Medicine/University of Basrah

² Biology Department/College of Pure Sciences/University of Thi Qar

³ Head of Chimarism Laboratory, Goethe University Hospital, Frankfurt, Germany

⁴ Head of Division of Stem Cell Transplantation and Immunology, Goethe University Hospital, Frankfurt, Germany

10.21608/ejmm.2025.386046.1655

Abstract

Background: Asthma is a chronic inflammatory condition causes chest tightness, wheezing, coughing, and shortness of breath. Objectives: To assess the levels of IL-9, IL-13, and hs-C-reactive protein in asthmatic patients and controls and assessing level of IgA in all studied cases to investigate presence of IgA deficiency if present. Methodology: A case control study was carried out during (October-April 2024). Out of 380 randomly selected cases with age range (7-80 years), 250 were asthmatic patients and 130 healthy controls. Immunological tests were done by using ELISA to measure levels of IgA, IL-9, IL-13 and hs-CRP. Results: IgA, IL-9 and hs-CRP levels were increased significantly in patients with recurrent respiratory tract infection (RTI) at p-value<0.05. Levels of IgA, IL-9 and IL-13 were increased non-significantly in atopy patient, except hs-CRP. Weak negative correlation between age group and both IL-9 and hs-CRP, IgA scored a moderate positive correlation with IL-9, and moderate positive correlation with both IL-13 and hs-CRP. IL-9 scored moderate positive correlation with IL-13 and weak positive correlation with hs-CRP. IL-13 scored very weak positive correlation with hs-CRP. Conclusion: Receiver Operating Characteristic (ROC) test indicated that all patients have positive results compared with control group, 77% of patients with IgA level were more than or within average of control group, and 23% were less the average of control group. Regarding to IL-9 and IL-13, more than 60% of patients have cytokines mean more than or within the mean of control group. Regarding hs-CRP, it was less specific indicator than other parameters.

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