The Role of DAB1 and LRRC1 Gene Polymorphisms in the Pathogenesis of Vitiligo

Document Type : New and original researches in the field of Microbiology.

Authors

1 Medical Biochemistry & Molecular Biology Department, Faculty of Medicine, Menofia University, Egypt

2 Biochemistry Department, Faculty of science, Tanta University, Egypt

3 Biochemistry Division, Department of chemistry, Faculty of science, Menoufia University, Shebin El-Kom, Egypt

10.21608/ejmm.2025.389407.1673

Abstract

Background: Psychological stress undoubtedly plays a part in causing and aggravating vitiligo and influencing how successfully it is treated. Genetic variations in Disabled-1 (DAB1) have been linked in a number of genetic studies to neurodevelopmental diseases, such as autism spectrum disorders and schizophrenia. Objectives: Neurodevelopmental susceptibility in patients with DAB1 polymorphism may have an effect on the pathogenesis of vitiligo. Our goal was to find out if the pathophysiology of vitiligo is related to the DAB1 (rs10889039) in a region on chromosome 1p32.2-p32.1 and Leucine Rich Repeat Containing 1 (LRRC1) rs9349687 in a region on chromosome 6q12.1 single nucleotide polymorphisms (SNPs). Methodology: One hundred people participated in the current study.  They were divided into two groups: 50 vitiligo patients and 50 healthy controls that were matched for age and gender.  LRRC1 (rs9349687) and DAB1 (rs10889039) were genotyped in each patient using real-time PCR. Results: Vitiligo patients had a higher frequency of G/T in DAB1 (rs10889039) than controls (60% vs 40%).  The genotype frequency and allelic distribution of LRRC1 (rs9349687) did not significantly differ between vitiligo patients and healthy controls. Conclusion: The pathophysiology of vitiligo may be influenced by the DAB1 (rs10889039) gene polymorphism.  New therapeutic options for vitiligo may be revealed by more research on its role in Reelin-DAB1 signalling and its influence on DAB1 protein, which was not examined in our study.

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