Evaluation of the Effect of Plant Extract on Microsporum canis in both vitro and in vivo

Document Type : New and original researches in the field of Microbiology.

Authors

1 Department of Botany, Faculty of Science, Mansoura University, 35516 Mansoura City, Egypt

2 Plant Pathology Research Institute-Agriculture Research Center-Giza-Egypt

3 Plant Pathology Department, Faculty of Agriculture, Mansoura University, 35516 Mansoura City, Egypt

Abstract

Background: Common skin infections, caused by dermatophytic fungi, often lead to suffering and discomfort. The ineffective conventional drugs, driving researchers to alternative therapies. Plant extracts possess antibacterial and antifungal properties and offer a possible natural remedy for dermatophytosis. Objective: With an emphasis on their antifungal and antioxidant qualities, the purpose of this study was to examine how plant extracts affected Microsporum canis. Methodology: To find the most efficient plant extract for combating dermatophytic fungi, several extracts were examined; the results showed that the extract with the most antifungal properties was the most successful. The influence of the plant extracts on fungal cells and cellular alterations was seen through microscopic analysis using light microscopy, transmission microscopy, and scanning electron microscopy. Mice were used as an animal model in this study to assess the plant extract's potential as a treatment. Results: The findings indicated that the majority of plant extracts considerably reduced Microsporum canis development, that Saussurea costus exhibited the strongest antifungal properties, and improved skin conditions in mice. Significant alterations in fungal cells were noted in microscopic ways, demonstrating how well the plant extracts worked to treat fungal infections.

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