Therapeutic Potential of Platelet-Rich Plasma in the Intestinal Phase of Trichinella spiralis Infection: An experimental Study

Zalat, Rabab S.; Atta, Shimaa A.; El-Wakil, Eman S.

doi:10.21608/ejmm.2025.407793.1801

Therapeutic Potential of Platelet-Rich Plasma in the Intestinal Phase of Trichinella spiralis Infection: An experimental Study

Document Type : New and original researches in the field of Microbiology.

Authors

¹ Department of Parasitology, Theodor Bilharz Research Institute, Kornaish El Nile, Warrak El-Hadar, Imbaba (P.O. 30), Giza 12411, Egypt

² Department of Immunology, Theodor Bilharz Research Institute, Kornaish El-Nile St, 12411, Giza

10.21608/ejmm.2025.407793.1801

Abstract

Background: Trichinellosis, a zoonotic disease with significant clinical ramifications, has been classified as an emerging re-emerging illness. Albendazole (ALB), the drug used to treat trichinellosis, has been connected to several adverse reactions. Researchers are thus motivated to seek out new alternative therapeutics. Platelet-rich plasma (PRP) has the advantage of being an autologous product with no known adverse effects, making it a viable option for biological therapies in various healthcare settings, including parasitic infection. Objective: This study aimed to look into PRP's therapeutic effects against the intestinal phase of murine trichinosis. Methodology: 30 Laboratory-bred albino rats were randomly divided into five groups: normal model, infected model, ALB, PRP, and combination of ALB and PRP. The effectiveness of the treatment was evaluated by parasitological, histopathological, and immunological analysis. Results: All treated groups showed a statistically significant difference from the Con Post. group (GII). Combining the ALB and PRP displayed the highest reduction (93%) with the lowest adult T. spiralis worm mean count (6 ± 2.2). The ALB efficacy (83%) was higher than PRP (73%), and the difference was statistically significant (p < 0.001). The combination of ALB and PRP produced the most noticeable histopathological improvements in the small intestine and MPO and IL-6 markers in serum. Conclusion: This study's findings highlight PRP's substantial therapeutic potential during the intestinal stage of a T. spiralis infection, opening up new research on PRP as an adjuvant or alternative treatment for helminthic diseases.

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