Polymorphism of rs2230806 in ABCA1 gene with coronary artery disease among Iraqi population

Al-faham, Layth; Hadi, Baraa A.; Kadhim, Majid H.; Salman, Mohammed N.; Algenabi, Abdul H.A.; Omara, Ali M.

doi:10.21608/ejmm.2025.407140.1798

Polymorphism of rs2230806 in ABCA1 gene with coronary artery disease among Iraqi population

Document Type : New and original researches in the field of Microbiology.

Authors

¹ Department of Clinical Biochemistry, College of Medicine, Kufa University, Najaf, Iraq

² Department of Medical and Pharmaceutical Science, College of Medicine, Jabir Ibn Hayyan University, Najaf, Iraq

³ Department of Clinical Biochemistry, College of Medicine, Al-Ameed University, Karbala, Iraq

10.21608/ejmm.2025.407140.1798

Abstract

Background: Coronary artery disease (CAD) is the major cause of morbidity and mortality. Mutations may be responsible for a CAD patient. The gene of human (ABCAl) ATP-binding cassette transporter A1 is central for cholesterol efflux from extrahepatic tissues, including macrophages, and has a specific role in high-density lipoprotein synthesis. Objective: The aim of this study was to investigate the association of the ABCA1 rs2230806 SNP in coronary artery disease among Iraqi subjects. Methodology: A case control study consisted of 400 subjects (200 confirmed CAD cases and 200 controls). Genotyping analysis of ABCA1 rs2230806 polymorphism was carried out using PCR-RFLP technique. The enzymatic method was used to determine the lipid profile. Results: Frequencies of the rs2230806 SNP's A allele carrier and AA genotype were significantly associated with reduced risk of CAD under different genetic models (codominant model: OR = 0.70, P<0.001; dominant model: OR = 1.84, P = 0.003; recessive model: OR = 0.40, P<0.001). Additionally, Patients with coronary artery disease (CAD) who carried the AA genotype of the variant appeared to have higher HDL-C and lower TC and TG compared with those who carried the AG and GG genotypes (P < 0.05). Conclusions: Our results reported that rs2230806 polymorphism of the ABCA1 gene was significantly associated with reduced CAD risk among Iraqi population. Carriers of rs2230806 A allele play a protective role in CAD and have a strong correlation with high HDL-C levels.

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