Association of IL-27 Single Nucleotide Polymorphism (rs153109) with Allergic Rhinitis in Egyptian Population

Document Type : New and original researches in the field of Microbiology.

Authors

1 Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

2 Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

3 Otorhinolaryngology, Head and Neck Surgery Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Abstract

Background: One worldwide health issue is allergic rhinitis (AR). It is an inflammatory disorder characterized by a failure in the regulation mechanism of the immune system. Interleukin 27 (IL-27) plays a critical function in immune-related illnesses and is a major mediator in controlling the differentiation of TCD4 + cells. Objectives: The goal of this study was to determine whether IL-27 Single Nucleotide Polymorphism (rs153109) correlates with the risk of AR in Egyptian population. Methodology: This study included 216 adult participants, consisted of 108 AR patients and 108 apparently healthy controls. Genotyping of the rs153109 SNP in the IL-27P28 gene promoter was executed by (PCR-RFLP) method. Results: The two study groups' demographic characteristics (gender and age) were matched. TT genotype was found to be significantly higher among AR patients compared to control group (65.7% versus 34.3% respectively) with OR of 3.65 at 95% CI. The CT and CC genotypes were protective factors, being more prevalent in controls and linked to a lower risk of AR. Conclusion: IL-27p28 SNP (rs153109) is associated with susceptibility to AR making it potentially valuable genetic biomarker for the Egyptian population's vulnerability to AR.

Keywords

Main Subjects

Files

Share

How to cite

Statistics