The Diversity of Bacteriocin and Its Antiviral Potential: An Overview

Document Type : Review articles

Authors

1 Department of Microbiology, Egyptian Drug (EDA), Formerly National organization for Drug Control and Research (NODCAR), Giza,12611,Egypt

2 Department of Microbiology and Immunology, Faculty of Pharmacy, Helwan University, Cairo, Egypt

3 Department of Microbiology and Immunology, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt

Abstract

The viral resistances to the known antiviral agent have raised the need for developing alternatives antiviral agents.one of the promising alternatives are bacteriocins. Bacteriocin are natural peptides ribosomal synthesized by gram negative and gram positive bacteria. Bacteriocins are secreted as a method for the producer to compete in the environment. Bacteriocin gene cluster can be found on plasmid or chromosome. Bacteriocins have presented wide range of activity against bacteria, fungi, virus and cancer cells and have a high margin of safety which encouraged its use in food and pharmaceutical applications. Nisin is one example of bacteriocins approved by FDA for use as food preservative. Bacteriocin nature variation is one of its unique qualities. Bacteriocin varies in physical, chemical, molecular and genetic nature. This variation have been studied and recoded over the years. In this review we discuss and summarized the diversity of bacteriocins and their different mechanism of actions against virus.  

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